Drug Action at the Molecular Level

Front Matter....Pages i-ix
Chemical constitution and prototropic equilibria in structure — activity analysis....Pages 1-39
Calculation of essential drug conformations and electron distributions....Pages 41-54
The conformation of hormonal peptides in solution....Pages 55-72
Structure and function of carbonic anhydrase: comparative studies of sulphonamide binding to human erythrocyte carbonic anhydrases B and C....Pages 73-91
Kinetic aspects of structure — activity relationships in the carbonic anhydrase — sulphonamide system....Pages 93-107
The haemoglobin molecule as a model drug receptor....Pages 109-126
Substrate and inhibitor binding to dihydrofolate reductase....Pages 127-150
The molecular basis for the inhibitory action of 6-(arylhydrazino)-pyrimidines on the replication-specific DNA polymerase III of Gram-positive bacteria....Pages 151-166
Structural and conformational studies on quinoxaline antibiotics in relation to the molecular basis of their interaction with DNA....Pages 167-189
The receptor site for chloramphenicol in vitro and in vivo....Pages 190-200
The mechanism of cytochrome P450-catalysed drug oxidations....Pages 201-212
Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic actions....Pages 213-233
Adenylate cyclase: actions and interactions of regulatory ligands....Pages 235-247
Properties and function of the acetylcholine receptor of vertebrate skeletal muscle....Pages 249-274
Back Matter....Pages 275-291