Pathophysiology of Plasma Protein Metabolism

Front Matter....Pages i-xiv
Large models in the study of protein metabolism....Pages 1-14
Optimal experiment design in plasma protein metabolic studies: Sequential optimal sampling schedules for quantifying kinetics....Pages 15-34
Formulation, identification and validation of mathematical models for plasma protein metabolic studies....Pages 35-70
Kinetic modelling for distribution and removal of plasma proteins with altered biological behaviour in vivo....Pages 71-86
Regulation of the interstitial distribution of plasma proteins....Pages 87-120
In vivo and in vitro regulation of albumin synthesis....Pages 121-139
In vitro and in vivo regulation of immunoglobulin synthesis....Pages 141-149
IgA immunoglobulin synthesis, catabolism and transport....Pages 151-172
Regulation of retained and secreted liver proteins....Pages 173-193
Metabolism of radiolabelled complement proteins in health and disease....Pages 195-220
Metabolic studies of acute-phase proteins....Pages 221-248
Significance of in vivo and in vitro metabolic studies of tumour-produced proteins....Pages 249-263
Fibrinogen and fibrinogen-related peptides in cancer....Pages 265-278
Studies of antithrombin turnover....Pages 279-298
Nutritional aspects of plasma protein metabolic studies: Protein-energy malnutrition....Pages 299-323
Nutritional aspects of plasma protein metabolic studies: Long-term treatment of chronic uraemia by a very-low-protein diet supplemented with essential amino acids and keto analogues....Pages 325-331
Kinetics of apolipoproteins A-I and A-II....Pages 333-355
The plasma apolipoproteins: Physiological properties and possible role in lipid disorders and atherogenesis....Pages 357-372
Role of cell-surface receptors in the behaviour in vivo of transferren....Pages 373-395
Back Matter....Pages 397-402