Dopaminergic Systems and their Regulation

Front Matter....Pages i-xv
Front Matter....Pages 1-1
A Quarter Century of Brain Dopamine Research....Pages 3-18
Dopamine Release and Metabolism in Awake Rats after Systemic Neuroleptics as Studied by Brain Dialysis....Pages 19-34
Mechanisms Underlying the Modulation of Dopamine Release through Presynaptic Muscarinic Receptors....Pages 35-43
Dopamine Autoreceptors: Studies on their Distribution and Mode of Action....Pages 45-61
Effects of D-1 and D-2 Receptor Stimulation on Single Unit Activity in the Substantia Nigra and Globus Pallidus....Pages 63-78
Regulation of Agonist Interactions with Brain D-1 Dopamine Receptors....Pages 79-95
Functional States of Dopamine Receptors....Pages 97-109
Autoradiographic Visualization and Quantification of Dopamine Receptors and Uptake Sites in the Rat and Human CNS....Pages 111-130
Dopaminergic Behavioral Responses and Classes of Binding Sites Distinguished by Discriminant Benzamide Derivatives....Pages 131-152
Transduction Mechanisms at Dopamine Receptors....Pages 153-163
DARPP-32: A Dopamine-regulated Phosphoprotein in the Basal Ganglia....Pages 165-179
Pharmacological Characterization of the Dopamine Renal Vascular Receptor....Pages 181-194
Conclusive Evidence for Two Subtypes of Peripheral Dopamine Receptors....Pages 195-212
Dynamic Changes in Brain Dopamine Metabolism During Movement....Pages 213-221
Neuropeptide-Dopamine Interactions: Focus on Neurotensin....Pages 223-241
Dopamine Neurone Destruction in Human and Animal Parkinsonism....Pages 243-259
Behavioural Compensation after Dopamine Grafts in Brain....Pages 261-272
Post-mortem Studies of Dopaminergic Function in Schizophrenia....Pages 273-284
Amygdala Dopamine Asymmetry in Schizophrenia: Neurochemical Evidence for a Left Temporal Lobe Dysfunction....Pages 285-291
Separate Molecular Mechanisms for Estrogen-induced Up- and Down-regulation of Striatal Dopamine Receptors....Pages 293-302
Front Matter....Pages 1-1
Midbrain Dopamine Neurons: Electrophysiological Studies on the Acute Effects of Estrogen....Pages 303-311
Neurochemical Substrates Underlying Estrogen Effect at Nigro-striatal Level....Pages 313-321
Effect of Oestrogen and Prolactin on Dopamine Receptors — Further Characterization....Pages 323-337
Modulation of Dopamine Sensitive Dyskinesia by Estradiol and Prolactin in Primates....Pages 339-342
Differentiation of Postsynaptic Dopamine Receptor Density Altered by Estrogen and the Modulatory Role of Prolactin....Pages 343-358
Down-regulation of Dopamine Autoreceptors by Estrogens: Physiological Control....Pages 359-371
Front Matter....Pages 373-373
Novel Dopamine Agonists of the Indolylbutylamine Type: Pre- Versus Postsynaptic Activity in Various in vivo and in vitro Models....Pages 375-376
Neuropharmacological Profile of a New Series of Dopamine Agonists: N-n-Propyl-hexahydronaphthoxazines....Pages 377-378
Eticlopride, a Potent Substituted Benzamide Compound Useful for the Labelling of Rat Central Dopamine-D2 Receptors in vitro and in vivo....Pages 379-380
N,N-di-n-Propyl-7-hydroxy-2-aminotetralin (DP-7-AT), a Selective Dopamine Autoreceptor Agonist?....Pages 381-382
Some Binding Characteristics of 3H—SCH 23390 — A Specific D1 Receptor Antagonist....Pages 383-384
Benzazepine Derivatives: Nature of the Selective and Stereospecific Interactions of SK&F 38393 and SCH 23390 with Brain D-1 Receptors....Pages 385-386
Effects of SCH 23390 on Neurotransmitter-stimulated Cyclic AMP Accumulation in Mammalian Brain and Teleost Retina....Pages 387-388
The Interaction of Ergot Alkaloids with Barbiturate: The Dependence of Alkaloids Action on Dopaminergic Receptors....Pages 389-392
Minaprine, a New Atypical Stimulant of Dopaminergic Neurotransmissions — I: Behavioural Profile in Rodents....Pages 393-394
Minaprine, a New Atypical Stimulant of Dopaminergic Neurotransmissions — II: Evidence for a Dual Pre- and Post-synaptic Mechanism of Action....Pages 395-396
[3H]-Nomifensine Labels Sites Associated with Neuronal Uptake Pumps for Both Dopamine and Norepinephrine in the CNS....Pages 397-398
Effects of Antidepressant Drugs on [3H]Dopamine Uptake and Storage by Rat Striatal Vesicles....Pages 399-400
Changes in Reactivity of Hippocampal Dopaminergic System after Repeated Imipramine Injection....Pages 401-402
Front Matter....Pages 403-404
Characterization of the in vitro Binding of [3H] DP-5,6-ADTN to Rat Striatal Membranes....Pages 373-373
Characterization of the Binding of 3H-2-Amino-6,7-dihydroxy-tetrahydronaphthalene (ADTN) to Rat Striatal Membranes: Similarities and Discrepancies between D1 and D3 as well as D2 and D4 Dopamine Receptors....Pages 405-406
3-PPP Enantiomers and Brain Sigma Opiate Sites: Discrepancies between in vitro and in vivo Observations....Pages 407-408
The Dopaminergic System in the Hippocampus: Site of Action for Antipsychotic Activity of Neuroleptics?....Pages 409-410
Neuroleptic-induced Dyskinesia in Dogs: Relative Potency of Antipsychotic Drugs in a Possible Model for Human Dyskinesias....Pages 411-412
Modulatory Role of Prolactin in the Development of an Elevated Density of Striatal Dopamine Receptors after the Chronic Administration of Domperidone or Sulpiride....Pages 413-414
D2 Autoreceptors Regulating Dopamine Synthesis in Synaptosomes: Modulation of Sensitivity with Acute and Chronic Treatments....Pages 415-416
Regulation of Agonist Binding to D-2 Receptors....Pages 417-418
GM1 Ganglioside Treatment Affects the Plasticity of Striatal Dopamine Receptors....Pages 419-420
Studies Directed towards the Isolation of the D2 Dopamine Receptor....Pages 421-422
Characteristics of the Solubilised D-2 Dopamine Receptor from Rat Striatum....Pages 423-424
Constant-light Induced Down-regulation of Dopamine Receptors in Retina....Pages 425-426
Biochemical and Functional Evidence for a Marked Dopamine Releasing Action of N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) in Mouse Brain....Pages 427-428
Protection against the Nigrostriatal Dopaminergic Neurotoxicity of 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in Mice by Monoamine Oxidase Inhibitors....Pages 429-430
Parkinsonism Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Marmoset: Effects of Bromocriptine and L-Dopa....Pages 431-432
MPTP Infusion into Rat Substantia Nigra Causes Hypokinesia and Bradykinesia which are Reversed by L-Dopa Treatment....Pages 433-434
A Study of Peptide-Dopamine Interactions in the Rat Striata....Pages 435-436
Repeated Administration with Enkephalin into the A-10 Dopamine Region Produces Supersensitivity of the Mesolimbic Dopamine System....Pages 437-438
Prostaglandins can Selectively Modify Striatal Dopamine Function....Pages 439-440
Front Matter....Pages 441-442
Alterations in Rat Forebrain Dopamine Function by Manipulations of the Intralaminar Thalamus: Causal Control or Casual Coincidence?....Pages 443-444
Long-term Locomotor and Cognitive Deficits in Rats with 6-OHDA Lesions of the VTA: A Model for Transplantation Studies....Pages 373-373
Independent Dopamine D-1 and D-2 Receptor Regulation of Dopamine Agonist-induced Hyperactivity in 6-OHDA Lesioned Rats; but not in Normal Rats....Pages 445-446
Inhibition of Dopa-production in Striatal Synaptosomes by the R(−) and the S(+) Enantiomers of Apomorphine....Pages 447-448
α-Methyl-p-tyrosine Induced Disappearance of Dopamine in Substantia Nigra: Effect of Apomorphine, Haloperidol and GBL....Pages 449-450
Regulation of the Synaptosomal Tyrosine Hydroxylase Activity via Presynaptic Receptors in the Nucleus Accumbens of Rats....Pages 451-452
Dopaminergic Antagonists Enhance Tyrosine Hydroxylase Activation in Depolarised Striatal Slices....Pages 453-454
Regulation of the Release of Dopamine from Striatal Synaptosomes by Nicotinic Acetylcholine Receptors....Pages 455-456
The Tuberohypophyseal Dopamine System: Dopaminergic Modulation of Vasopressin Release. Characterization of Release and Metabolism of3H-Dopamine....Pages 457-458
D-1 and D-2 Dopaminergic Receptors Regulate Phosphorylation of Synaptic Vesicle Phosphoproteins in Rat Neurohypophysis....Pages 459-460
Striatal Dopaminergic Terminal Field Excitability....Pages 461-462
Role of Hydroxylase Cofactor in Regulating Dopamine Synthesis: Relevance to Neurological Disorders....Pages 463-465
Dopamine Brain Metabolism in Diabetic Rats....Pages 467-468
Brain Dopamine and Other Neurotransmitters in Neuronal Intranuclear Inclusion Body Disorder....Pages 469-470
Distribution of DOPAC and HVA in Human Brain Using Capillary GC and GC-MS....Pages 471-474
Characterization of the Synaptosomal Dopamine Uptake in Studies with Postmortem Human Brain....Pages 475-476
Increase in Urine Volume Following Acute Administration of Haloperidol in Adult Rats....Pages 477-478
The Antagonist Effects of SCH 23390 at Peripheral Dopamine Receptors....Pages 479-480
Cardio-vascular Effects of Intrathecal Thoracic Injections of Apomorphine....Pages 481-482
Front Matter....Pages 483-484
Metoclopramide and SCH 23390 can Enhance Cholinergic Mediated Contractions of Guinea Pig Bladder....Pages 485-486
Back Matter....Pages 487-488
....Pages 373-373